My Bibliography

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Henry N, Fraser JF, Chappell J, Langley T, Roberts JM. Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review. Transl Stroke Res. 2023 Jun;14(3):283-296. doi: 10.1007/s12975-022-01080-x. Epub 2022 Sep 15. Review. PubMed PMID: 36109476; PubMed Central PMCID: PMC10160197.

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Zinck GE, Chappell J. Structurally Guided Reprogramming of Valerenadiene Synthase. Biochemistry. 2021 Dec 28;60(51):3868-3878. doi: 10.1021/acs.biochem.1c00523. Epub 2021 Dec 13. PubMed PMID: 34898176.

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Tateno M, Stone BJ, Srodulski SJ, Reedy S, Gawriluk TR, Chambers TM, Woodward J, Chappell J, Kempinski CF. Synthetic Biology-derived triterpenes as efficacious immunomodulating adjuvants. Sci Rep. 2020 Oct 13;10(1):17090. doi: 10.1038/s41598-020-73868-6. PubMed PMID: 33051497; PubMed Central PMCID: PMC7553918.

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Ladhari A, Chappell J. Unravelling triterpene biosynthesis through functional characterization of an oxidosqualene cyclase (OSC) from Cleome arabica L. Plant Physiol Biochem. 2019 Nov;144:73-84. doi: 10.1016/j.plaphy.2019.09.035. Epub 2019 Sep 21. PubMed PMID: 31561200.

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Cai Y, Whitehead P, Chappell J, Chapman KD. Mouse lipogenic proteins promote the co-accumulation of triacylglycerols and sesquiterpenes in plant cells. Planta. 2019 Jul;250(1):79-94. doi: 10.1007/s00425-019-03148-9. Epub 2019 Mar 27. PubMed PMID: 30919065.

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Kempinski C, Jiang Z, Zinck G, Sato SJ, Ge Z, Clemente TE, Chappell J. Engineering linear, branched-chain triterpene metabolism in monocots. Plant Biotechnol J. 2019 Feb;17(2):373-385. doi: 10.1111/pbi.12983. Epub 2018 Oct 16. PubMed PMID: 29979490; PubMed Central PMCID: PMC6335073.

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Kempinski C, Chappell J. Engineering triterpene metabolism in the oilseed of Arabidopsis thaliana. Plant Biotechnol J. 2019 Feb;17(2):386-396. doi: 10.1111/pbi.12984. Epub 2018 Jul 31. PubMed PMID: 29979486; PubMed Central PMCID: PMC6335079.

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Jiang Z, Kempinski C, Kumar S, Kinison S, Linscott K, Nybo E, Janze S, Wood C, Chappell J. Agronomic and chemical performance of field-grown tobacco engineered for triterpene and methylated triterpene metabolism. Plant Biotechnol J. 2018 Jun;16(6):1110-1124. doi: 10.1111/pbi.12855. Epub 2018 Jan 3. PubMed PMID: 29069530; PubMed Central PMCID: PMC5978867.

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Majee M, Kumar S, Kathare PK, Wu S, Gingerich D, Nayak NR, Salaita L, Dinkins R, Martin K, Goodin M, Dirk LMA, Lloyd TD, Zhu L, Chappell J, Hunt AG, Vierstra R, Huq E, Downie AB. KELCH F-BOX protein positively influences Arabidopsis seed germination by targeting PHYTOCHROME-INTERACTING FACTOR1. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4120-E4129. doi: 10.1073/pnas.1711919115. Epub 2018 Apr 9. PubMed PMID: 29632208; PubMed Central PMCID: PMC5924874.

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Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S. Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593. ACS Synth Biol. 2017 Dec 15;6(12):2339-2349. doi: 10.1021/acssynbio.7b00249. Epub 2017 Oct 11. PubMed PMID: 29019653.

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Browne DR, Jenkins J, Schmutz J, Shu S, Barry K, Grimwood J, Chiniquy J, Sharma A, Niehaus TD, Weiss TL, Koppisch AT, Fox DT, Dhungana S, Okada S, Chappell J, Devarenne TP. Draft Nuclear Genome Sequence of the Liquid Hydrocarbon-Accumulating Green Microalga Botryococcus braunii Race B (Showa). Genome Announc. 2017 Apr 20;5(16). doi: 10.1128/genomeA.00215-17. PubMed PMID: 28428306; PubMed Central PMCID: PMC5399265.

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Kumar S, Kempinski C, Zhuang X, Norris A, Mafu S, Zi J, Bell SA, Nybo SE, Kinison SE, Jiang Z, Goklany S, Linscott KB, Chen X, Jia Q, Brown SD, Bowman JL, Babbitt PC, Peters RJ, Chen F, Chappell J. Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha. Plant Cell. 2016 Oct;28(10):2632-2650. doi: 10.1105/tpc.16.00062. Epub 2016 Sep 20. PubMed PMID: 27650333; PubMed Central PMCID: PMC5134972.

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Linscott KB, Niehaus TD, Zhuang X, Bell SA, Chappell J. Mapping a kingdom-specific functional domain of squalene synthase. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1049-1057. doi: 10.1016/j.bbalip.2016.06.008. Epub 2016 Jun 15. PubMed PMID: 27320012.

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Jiang Z, Kempinski C, Chappell J. Extraction and Analysis of Terpenes/Terpenoids. Curr Protoc Plant Biol. 2016;1:345-358. doi: 10.1002/cppb.20024. Epub 2016 Jun 10. PubMed PMID: 27868090; PubMed Central PMCID: PMC5113832.

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Suza WP, Chappell J. Spatial and temporal regulation of sterol biosynthesis in Nicotiana benthamiana. Physiol Plant. 2016 Jun;157(2):120-34. doi: 10.1111/ppl.12413. Epub 2016 Mar 7. PubMed PMID: 26671544.

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Ricigliano V, Kumar S, Kinison S, Brooks C, Nybo SE, Chappell J, Howarth DG. Regulation of sesquiterpenoid metabolism in recombinant and elicited Valeriana officinalis hairy roots. Phytochemistry. 2016 May;125:43-53. doi: 10.1016/j.phytochem.2016.02.011. Epub 2016 Feb 23. PubMed PMID: 26920719.

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Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M. Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens. mBio. 2016 Apr 26;7(2):e00221-16. doi: 10.1128/mBio.00221-16. PubMed PMID: 27118587; PubMed Central PMCID: PMC4850256.

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Jiang Z, Kempinski C, Bush CJ, Nybo SE, Chappell J. Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism. Plant Physiol. 2016 Feb;170(2):702-16. doi: 10.1104/pp.15.01548. Epub 2015 Nov 24. PubMed PMID: 26603654; PubMed Central PMCID: PMC4734568.

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Parveen I, Wang M, Zhao J, Chittiboyina AG, Tabanca N, Ali A, Baerson SR, Techen N, Chappell J, Khan IA, Pan Z. Investigating sesquiterpene biosynthesis in Ginkgo biloba: molecular cloning and functional characterization of (E,E)-farnesol and α-bisabolene synthases. Plant Mol Biol. 2015 Nov;89(4-5):451-62. doi: 10.1007/s11103-015-0381-3. Epub 2015 Oct 6. PubMed PMID: 26442918.

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Zhuang X, Chappell J. Building terpene production platforms in yeast. Biotechnol Bioeng. 2015 Sep;112(9):1854-64. doi: 10.1002/bit.25588. Epub 2015 May 12. PubMed PMID: 25788404.

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Khan NE, Nybo SE, Chappell J, Curtis WR. Triterpene hydrocarbon production engineered into a metabolically versatile host--Rhodobacter capsulatus. Biotechnol Bioeng. 2015 Aug;112(8):1523-32. doi: 10.1002/bit.25573. Epub 2015 May 12. PubMed PMID: 25728701.

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Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol. 2015 Jul 17;10(7):1729-36. doi: 10.1021/acschembio.5b00145. Epub 2015 May 4. PubMed PMID: 25897591; PubMed Central PMCID: PMC4570970.

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Kempinski C, Jiang Z, Bell S, Chappell J. Metabolic engineering of higher plants and algae for isoprenoid production. Adv Biochem Eng Biotechnol. 2015;148:161-99. doi: 10.1007/10_2014_290. Review. PubMed PMID: 25636485.

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Bell SA, Niehaus TD, Nybo SE, Chappell J. Structure-function mapping of key determinants for hydrocarbon biosynthesis by squalene and squalene synthase-like enzymes from the green alga Botryococcus braunii race B. Biochemistry. 2014 Dec 9;53(48):7570-81. doi: 10.1021/bi501264s. Epub 2014 Nov 26. PubMed PMID: 25393512.

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Bell SA, Chappell J. Now playing: farnesol in the biofilm. Chem Biol. 2014 Nov 20;21(11):1421-2. doi: 10.1016/j.chembiol.2014.11.001. Epub 2014 Nov 20. PubMed PMID: 25457121.

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Bedewitz MA, Góngora-Castillo E, Uebler JB, Gonzales-Vigil E, Wiegert-Rininger KE, Childs KL, Hamilton JP, Vaillancourt B, Yeo YS, Chappell J, DellaPenna D, Jones AD, Buell CR, Barry CS. A root-expressed L-phenylalanine:4-hydroxyphenylpyruvate aminotransferase is required for tropane alkaloid biosynthesis in Atropa belladonna. Plant Cell. 2014 Sep;26(9):3745-62. doi: 10.1105/tpc.114.130534. Epub 2014 Sep 16. PubMed PMID: 25228340; PubMed Central PMCID: PMC4213168.

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Khatri W, Hendrix R, Niehaus T, Chappell J, Curtis WR. Hydrocarbon production in high density Botryococcus braunii race B continuous culture. Biotechnol Bioeng. 2014 Mar;111(3):493-503. doi: 10.1002/bit.25126. Epub 2013 Nov 22. PubMed PMID: 24122424.

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Yeo YS, Nybo SE, Chittiboyina AG, Weerasooriya AD, Wang YH, Góngora-Castillo E, Vaillancourt B, Buell CR, DellaPenna D, Celiz MD, Jones AD, Wurtele ES, Ransom N, Dudareva N, Shaaban KA, Tibrewal N, Chandra S, Smillie T, Khan IA, Coates RM, Watt DS, Chappell J. Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. J Biol Chem. 2013 Feb 1;288(5):3163-73. doi: 10.1074/jbc.M112.415836. Epub 2012 Dec 14. PubMed PMID: 23243312; PubMed Central PMCID: PMC3561538.

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Cai B, Siminszky B, Chappell J, Dewey RE, Bush LP. Enantioselective demethylation of nicotine as a mechanism for variable nornicotine composition in tobacco leaf. J Biol Chem. 2012 Dec 14;287(51):42804-11. doi: 10.1074/jbc.M112.413807. Epub 2012 Oct 25. PubMed PMID: 23100254; PubMed Central PMCID: PMC3522278.

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Chappell J. Biochemistry: Another aspect of nature's ingenuity. Nature. 2012 Dec 6;492(7427):50-1. doi: 10.1038/nature11754. Epub 2012 Nov 21. PubMed PMID: 23172140.

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Wurtele ES, Chappell J, Jones AD, Celiz MD, Ransom N, Hur M, Rizshsky L, Crispin M, Dixon P, Liu J, P Widrlechner M, Nikolau BJ. Medicinal plants: a public resource for metabolomics and hypothesis development. Metabolites. 2012 Nov 21;2(4):1031-59. doi: 10.3390/metabo2041031. PubMed PMID: 24957774; PubMed Central PMCID: PMC3901233.

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Wu S, Jiang Z, Kempinski C, Eric Nybo S, Husodo S, Williams R, Chappell J. Engineering triterpene metabolism in tobacco. Planta. 2012 Sep;236(3):867-77. doi: 10.1007/s00425-012-1680-4. Epub 2012 Jun 24. PubMed PMID: 22729821; PubMed Central PMCID: PMC3810399.

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Niehaus TD, Kinison S, Okada S, Yeo YS, Bell SA, Cui P, Devarenne TP, Chappell J. Functional identification of triterpene methyltransferases from Botryococcus braunii race B. J Biol Chem. 2012 Mar 9;287(11):8163-73. doi: 10.1074/jbc.M111.316059. Epub 2012 Jan 12. PubMed PMID: 22241476; PubMed Central PMCID: PMC3318757.

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Góngora-Castillo E, Fedewa G, Yeo Y, Chappell J, DellaPenna D, Buell CR. Genomic approaches for interrogating the biochemistry of medicinal plant species. Methods Enzymol. 2012;517:139-59. doi: 10.1016/B978-0-12-404634-4.00007-3. PubMed PMID: 23084937; PubMed Central PMCID: PMC3926661.

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Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J. Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12260-5. doi: 10.1073/pnas.1106222108. Epub 2011 Jul 11. PubMed PMID: 21746901; PubMed Central PMCID: PMC3145686.

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Faraldos JA, Wu S, Chappell J, Coates RM. Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. J Am Chem Soc. 2010 Mar 10;132(9):2998-3008. doi: 10.1021/ja909251r. PubMed PMID: 20148554; NIHMSID:NIHMS178766.

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Weiss TL, Johnston JS, Fujisawa K, Sumimoto K, Okada S, Chappell J, Devarenne TP. producing green microalga Botryococcus braunii var. Berkeley (Showa) (Chlorophyta). Journal of Phycology. 2010; 46:634.

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Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med. 2009 Sep;15(9):1023-30. doi: 10.1038/nm.2018. Epub 2009 Aug 9. PubMed PMID: 19668192; PubMed Central PMCID: PMC2882165.

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O'Maille PE, Malone A, Dellas N, Andes Hess B Jr, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel JP. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol. 2008 Oct;4(10):617-23. doi: 10.1038/nchembio.113. Epub 2008 Sep 7. PubMed PMID: 18776889; PubMed Central PMCID: PMC2664519.

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Lee S, Chappell J. Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora. Plant Physiol. 2008 Jul;147(3):1017-33. doi: 10.1104/pp.108.115824. Epub 2008 May 8. PubMed PMID: 18467455; PubMed Central PMCID: PMC2442544.

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Chappell J. Production platforms for the molecular pharming of alkaloid diversity. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):7897-8. doi: 10.1073/pnas.0803930105. Epub 2008 Jun 9. PubMed PMID: 18541922; PubMed Central PMCID: PMC2430336.

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Chappell J, Grotewold E. Plant biotechnology--predictive, green and quantitative. Curr Opin Biotechnol. 2008 Apr;19(2):129-30. doi: 10.1016/j.copbio.2008.02.008. Epub 2008 Apr 2. PubMed PMID: 18387798.

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Wu S, Chappell J. Metabolic engineering of natural products in plants; tools of the trade and challenges for the future. Curr Opin Biotechnol. 2008 Apr;19(2):145-52. doi: 10.1016/j.copbio.2008.02.007. Epub 2008 Mar 28. Review. PubMed PMID: 18375112.

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Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem. 2007 Oct 26;282(43):31744-54. doi: 10.1074/jbc.M703378200. Epub 2007 Aug 22. PubMed PMID: 17715131; PubMed Central PMCID: PMC2695360.

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Faraldos JA, Wu S, Chappell J, Coates RM. Conformational Analysis of (+)-Germacrene A by Variable Temperature NMR and NOE Spectroscopy. Tetrahedron. 2007 Sep 6;63(32):7733-7742. doi: 10.1016/j.tet.2007.04.037. PubMed PMID: 20617157; PubMed Central PMCID: PMC2898143.

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Takahashi S, Yeo Y, Greenhagen BT, McMullin T, Song L, Maurina-Brunker J, Rosson R, Noel JP, Chappell J. Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol Bioeng. 2007 May 1;97(1):170-81. doi: 10.1002/bit.21216. PubMed PMID: 17013941; PubMed Central PMCID: PMC2859293.

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Xu DM, Shen YX, Chappell J, Cui MW, Nielsen MT. Biochemical and molecular characterization of nicotine demethylase in tobacco. Physiologia plantarum. 2007; 129:307.

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Wu S, Schalk M, Clark A, Miles RB, Coates R, Chappell J. Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants. Nat Biotechnol. 2006 Nov;24(11):1441-7. doi: 10.1038/nbt1251. Epub 2006 Oct 22. PubMed PMID: 17057703.

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Deguerry F, Pastore L, Wu S, Clark A, Chappell J, Schalk M. The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases. Arch Biochem Biophys. 2006 Oct 15;454(2):123-36. doi: 10.1016/j.abb.2006.08.006. Epub 2006 Aug 23. PubMed PMID: 16970904.

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Greenhagen BT, O'Maille PE, Noel JP, Chappell J. Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9826-31. doi: 10.1073/pnas.0601605103. Epub 2006 Jun 19. PubMed PMID: 16785438; PubMed Central PMCID: PMC1502538.