Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications.
Epigenomes.
2024 Feb 4;8(1). doi: 10.3390/epigenomes8010007. Review. PubMed PMID:
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Eutherian-Specific Functions of BetaM Acquired through Atp1b4 Gene Co-Option in the Regulation of MyoD Expression.
Life (Basel).
2023 Feb 2;13(2). doi: 10.3390/life13020414. PubMed PMID:
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Epigenetic and pharmacological control of pigmentation via Bromodomain Protein 9 (BRD9).
Pigment Cell Melanoma Res.
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SWI/SNF Chromatin Remodeling Enzymes in Melanoma.
Epigenomes.
2022 Mar 18;6(1). doi: 10.3390/epigenomes6010010. Review. PubMed PMID:
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Role of the CXCR4-LASP1 Axis in the Stabilization of Snail1 in Triple-Negative Breast Cancer.
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Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation.
Epigenetics Chromatin.
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SETD7 in cardiomyocyte differentiation and cardiac function.
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BAF60A mediates interactions between the microphthalmia-associated transcription factor and the BRG1-containing SWI/SNF complex during melanocyte differentiation.
J Cell Physiol.
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Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells.
PLoS One.
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BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation.
Nucleic Acids Res.
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Correction: RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration.
Oncotarget.
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RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration.
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MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy.
J Mol Cell Cardiol.
2015 Nov;88:101-10. doi: 10.1016/j.yjmcc.2015.09.010. Epub 2015 Sep 24. PubMed PMID:
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RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
PLoS One.
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Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.
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SWI/SNF chromatin remodeling enzymes in melanocyte differentiation and melanoma.
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SWI/SNF chromatin remodeling enzymes are associated with cardiac hypertrophy in a genetic rat model of hypertension.
J Cell Physiol.
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SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression.
PLoS One.
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CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells.
Gene Regul Syst Bio.
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BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene.
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Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer.
Cancer Res.
2012 Jun 15;72(12):3091-104. doi: 10.1158/0008-5472.CAN-11-3546. Epub 2012 Apr 13. PubMed PMID:
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A Micro-RNA Connection in BRaf(V600E)-Mediated Premature Senescence of Human Melanocytes.
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Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness.
Mol Cancer.
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The obesity-associated Fto gene is a transcriptional coactivator.
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SWItching on the transcriptional circuitry in melanoma.
Epigenetics.
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ATP dependent chromatin remodeling enzymes in embryonic stem cells.
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Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.
Oncogene.
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Chromatin remodeling in embryonic stem cells: regulating the balance between pluripotency and differentiation.
J Cell Physiol.
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The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
J Biol Chem.
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Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers.
Nat Rev Genet.
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MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex.
Mol Cell Biol.
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BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.
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Mol Biol Cell.
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Unfolding heterochromatin for replication.
Nat Genet.
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The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture.
J Biol Chem.
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MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes.
J Biol Chem.
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Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
Nat Genet.
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Mol Gen Genet.
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Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.
Mol Cell Biol.
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Carbon regulation of ribosomal genes in Neurospora crassa occurs by a mechanism which does not require Cre-1, the homologue of the Aspergillus carbon catabolite repressor, CreA.
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