HTG EdgeSeq Mouse mRNA Tumor Response Panel
Measure 1,659 mouse mRNA targets in one RNA extraction-free assay. The HTG EdgeSeq Mouse mRNA Tumor Response Panel leverages the sensitivity and dynamic range of next-generation sequencing (NGS) to measure genes implicated in preclinical mouse models of human disease.
Built around core signaling pathways and immune response mechanisms in oncology and other disease states, the HTG EdgeSeq Mouse mRNA Tumor Response Panel enables multiplex profiling from a variety of sample types, including a single section of formalin-fixed, paraffin-embedded (FFPE) tissue, cell lines, and extracted RNA samples. Applications include modeling oncogenesis, studying the immune response to mouse and patient-derived xenografts, and investigational therapeutic response studies. HTG’s extraction-free HTG EdgeSeq assays are automated on the HTG EdgeSeq system or can be run in HTG’s VERI/O service laboratory.
For Research Use Only. Not for Use in Diagnostic Procedures.
2020 HTG EdgeSeq Mouse mRNA Tumor Response Panel Research Grants
Congratulations to our two grant recipients!
Amir Horowitz, PhD
Icahn School of Medicine at Mount Sinai
Horowitz Laboratory
Venkateshwar Madka, PhD
University of Oklahoma
Stanton Young Biomedical Research Center
Features and Benefits
- Measure 1,659 transcripts in a single well: obtain a broad profile of genes associated with oncology, immunity, and inflammation
- Extraction-free chemistry: the simple workflow reduces extraction-associated data bias and sample loss
- Low sample input: reliable, reproducible performance from a single section of FFPE tissue
- Simplified data analysis: analyze results in the HTG EdgeSeq Reveal Data Suite, not a complicated RNASeq pipeline
Sample Requirements
| Sample Type | Recommended Sample Input |
|---|---|
Larger sample input amounts must be diluted. Please consult the assay package insert and HTG EdgeSeq System User Manual for more details. |
|
| FFPE Tissue | One 5 µm section |
| Cells | ≥3,000 cells |
| Extracted RNA from FFPE | 35 ng |
| Extracted RNA from Frozen | 10 - 35 ng |
Applications
- Preclinical disease modeling
- Elucidation of molecular mechanisms of tumorigenesis
- Compound screening and therapeutic response
- Developing mouse mRNA biomarker signatures
Ordering Information
When placing an order, please specify the catalog number. The HTG EdgeSeq Mouse mRNA Assay is compatible with Illumina sequencers.
Kit Configurations for use with Illumina Sequencers
916-010-208 HTG EdgeSeq Mouse mRNA Tumor Response Panel (2X8)
916-010-008 HTG EdgeSeq Mouse mRNA Tumor Response Panel (4X8)
916-010-224 HTG EdgeSeq Mouse mRNA Tumor Response Panel (1X24)
916-010-024 HTG EdgeSeq Mouse mRNA Tumor Response Panel (4X24)
916-010-096 HTG EdgeSeq Mouse mRNA Tumor Response Panel (1X96)
Kit Configurations for use with Ion Torrent Sequencers
916-010-308 HTG EdgeSeq Mouse mRNA Tumor Response Panel (2x8)
916-010-108 HTG EdgeSeq Mouse mRNA Tumor Response Panel (4x8)
916-010-324 HTG EdgeSeq Mouse mRNA Tumor Response Panel (1x24)
916-010-124 HTG EdgeSeq Mouse mRNA Tumor Response Panel (4x24)
916-010-196 HTG EdgeSeq Mouse mRNA Tumor Response Panel (1x96)
For Research Use Only. Not for Use in Diagnostic Procedures.
Resources and Publications
Learn more about the HTG EdgeSeq Mouse mRNA Tumor Response Panel
HTG EdgeSeq Mouse mRNA Tumor Response Panel Gene List
Download pdf 118KB
View External Link
HTG EdgeSeq Mouse mRNA Tumor Response Panel Product Sheet
Download pdf 168KB
Publications
Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis
View External Link
Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the Apcmin/+ mouse model
View External Link
Targeting cardiac fibrosis with engineered T cells
Download pdf 13.4MB
Learn More
For further information about the HTG EdgeSeq Mouse mRNA Tumor Response Panel, please fill out the registration form below or call us at (877) 507-3259.
Page last updated June 29, 2022