House Speaker Nancy Pelosi’s speech on Monday in San Francisco touting the benefits of the recently passed Infrastructure and Jobs Act was briefly interrupted when a heckler shouted the now-viral anti-President Biden chant. 

Pelosi was in the process of introducing someone to the rostrum when a person off camera yelled, "Let’s go, Brandon," the phrase that has gained traction among some Republicans and critics of the president, which is code for a derogatory message. 

Pelosi seemed to be taken aback for a moment but did not acknowledge the remark, according to the clip viewed by Fox News. Her office did not immediately respond to an after-hours email.

House Speaker Nancy Pelosi speaks

House Speaker Nancy Pelosi speaks about proposed investments in children to reduce economic disparity, during a news conference on Capitol Hill in Washington. (AP Photo/Manuel Balce Ceneta)

The chant caught on in October when a reporter for NBC Sports was interviewing NASCAR driver Brandon Brown, who had just won his first Xfinity Series race at Talladega. Fans were chanting "F--- Joe Biden," but the reporter said they were saying, "Let’s go Brandon."

President Joe Biden salutes as he exits Marine One on the South Lawn of the White House

President Joe Biden salutes as he exits Marine One on the South Lawn of the White House Dec. 20, 2021. (Drew Angerer/Getty Images)

Brown recently told the New York Times that he has no interest in politics.

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Pelosi’s press conference with Mayor London Breed and Rep. Mark DeSaulnier, D-Calif., came on the heels of Sen. Joe Manchin’s announcement Sunday that he will oppose Biden’s social spending bill. 

MANCHIN BLASTS WH STAFF FOR LEAKING ‘ABSOLUTELY INEXCUSABLE’ THINGS ABOUT HIM AFTER REJECTING BBB

The speaker promised to try and revive Biden’s Build Back Better plan and said in a statement that she is "hopeful that we will soon reach an agreement so that this vital legislation can pass as soon as possible next year."

Fox News' Gary Gastelu contributed to this report