1Neve Campbell, 1996
Jeff Kravitz//Getty Images Coming off of Party of Five and The Craft, 1996 was a massive year for Campbell, landing her the lead role in the series. Sidney Prescott knows no rest.
2Neve Campbell, 2020
Kevin Mazur/2020 MTV Movie & TV Awards//Getty Images In 2021, Campbell has become a TV guest star staple, recently starred in the film Clouds, as well as the TV series House of Cards, and of course, reprised her role as the unkillable Sidney Prescott in 2022's Scream 5.
3Drew Barrymore, 1996
Tom Wargacki//Getty Images Barrymore was explosive in the 90s, and this was one of the most iconic deaths in horror history.
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4Drew Barrymore, 2021
CBS Photo Archive//Getty Images Though Barrymore won't be appearing in Scream's new installment, she's thriving with a wildly successful (if not incredibly kooky) daytime talk show.
5Courteney Cox, 1996
Jeff Kravitz//Getty Images Scream is nothing without Courteney Cox and her insanely unethical journalist character, Gale Weathers. At the time, she was also starring on this indie sitcom you might have heard of called Friends. Just a little side project.
6Courteney Cox, 2020
BG002/Bauer-Griffin//Getty Images Cox is thriving in 2021, looking better than ever. She recently reunited with the Friends cast and has been making multiple TV guest spots. She also returned to Scream in 2022.
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7David Arquette, 1996
Jeff Kravitz//Getty Images Arquette's star was rising at the time that Scream came out, launching the TV star into movie star status, especially when he married co-star Courteney Cox.
8David Arquette, 2021
Leon Bennett//Getty Images Arquette has had quite a journey since Scream. Recently, he was a professional wrestler. Seriously. He retired from the gig back in 2021, just in time to come back to Scream as Sheriff Dewey Riley.
9Matthew Lillard, 1996
Ron Galella//Getty Images Scream helped launch Lillard from celebrity to superstar following Scream. He plays one of the two killers in the original.
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10Matthew Lillard, 2021
Kevin Winter//Getty Images Listen. This guy has stayed booked and busy following the original Scream, most notably thanks to the Scooby Doo series, where he voices Shaggy. He also co-starred in the NBC series, Good Girls.
11Rose McGowan, 1996
Ron Galella//Getty Images Rose McGowan was riding high in 1996, coming off a handful of well-known comedies. Her character did not fare well in Scream.
12Rose McGowan, 2021
Francine Orr//Getty Images In 2021, McGowan has shifted her role in Hollywood entirely. An integral player of the #MeToo movement, McGowan has become a vocal activist, speaking out for women who have experienced sexual trauma. Her political statements have become a divisive lightning rod in online discussion.
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13Jamie Kennedy, 1996
Ron Galella//Getty Images Coming into Scream, Kennedy was a relatively known face, having guested and co-starred in a handful of TV series.
14Jamie Kennedy, 2021
Michael S. Schwartz//Getty Images Since then, Kennedy continued to appear in TV series, having co-starred in the network drama, Ghost Whisperer. In 2022, Kennedy has a successful standup career.
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