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There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the idea of “Disease f (x)” as a preferred call to arms with which to prioritize research and programmatic development. The common mathematical notation f (x) represents the knowledge that outbreaks are a function of many variables that define the transmission trajectory of that pathogen …