Abstract
Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.
MeSH terms
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Aneuploidy*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Chromosomes, Human, Pair 3
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Cisplatin / administration & dosage
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Drug Resistance, Neoplasm
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Endodermal Sinus Tumor / diagnostic imaging*
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Endodermal Sinus Tumor / drug therapy
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Endodermal Sinus Tumor / genetics
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Etoposide / administration & dosage
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Fatal Outcome
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Female
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Humans
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Lung Neoplasms / diagnostic imaging*
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Lung Neoplasms / drug therapy
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Lung Neoplasms / genetics
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Octamer Transcription Factor-3 / genetics
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Octamer Transcription Factor-3 / metabolism*
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Radiography
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SOXB1 Transcription Factors / genetics*
Substances
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Octamer Transcription Factor-3
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POU5F1 protein, human
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SOX2 protein, human
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SOXB1 Transcription Factors
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Etoposide
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Cisplatin