A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy: understanding the Oct 3/4 and Sox 2 interaction

Cancer Biol Ther. 2013 Jan;14(1):1-4. doi: 10.4161/cbt.22624. Epub 2012 Oct 31.

Abstract

Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aneuploidy*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chromosomes, Human, Pair 3
  • Cisplatin / administration & dosage
  • Drug Resistance, Neoplasm
  • Endodermal Sinus Tumor / diagnostic imaging*
  • Endodermal Sinus Tumor / drug therapy
  • Endodermal Sinus Tumor / genetics
  • Etoposide / administration & dosage
  • Fatal Outcome
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics
  • Octamer Transcription Factor-3 / genetics
  • Octamer Transcription Factor-3 / metabolism*
  • Radiography
  • SOXB1 Transcription Factors / genetics*

Substances

  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • SOX2 protein, human
  • SOXB1 Transcription Factors
  • Etoposide
  • Cisplatin