An all-purpose antimalarial drug target

Cell Host Microbe. 2012 Jun 14;11(6):555-7. doi: 10.1016/j.chom.2012.05.008.

Abstract

The recent re-emphasis on malaria eradication has made developing drugs that block transmission and terminate latent disease critical. Most drugs do not affect the liver stages-an ability that is crucial to the latter goal. Addressing this problem, Hoepfner et al. (2012) uncover the parasite's lysyl-tRNA synthetase as a druggable target.

Publication types

  • Review
  • Comment

MeSH terms

  • Antimalarials / pharmacology*
  • Enzyme Inhibitors / pharmacology*
  • Fungi / chemistry*
  • Humans
  • Isocoumarins / pharmacology*
  • Lysine-tRNA Ligase / antagonists & inhibitors*
  • Plasmodium falciparum / enzymology*

Substances

  • Antimalarials
  • Enzyme Inhibitors
  • Isocoumarins
  • Lysine-tRNA Ligase