Molecular genetics of head and neck cancer (Review)

Shitij Arora; Prachi Aggarwal; Amit Pathak; Rekha Bhandari; Frantz Duffoo; Subhash C Gulati

doi:10.3892/mmr.2012.889

Molecular genetics of head and neck cancer (Review)

Mol Med Rep. 2012 Jul;6(1):19-22. doi: 10.3892/mmr.2012.889. Epub 2012 Apr 24.

Authors

Shitij Arora¹, Prachi Aggarwal, Amit Pathak, Rekha Bhandari, Frantz Duffoo, Subhash C Gulati

Affiliation

¹ Department of Internal Medicine, Wyckoff Heights Medical Center, New York-Presbyterian Health Care System, affiliated with Weil Medical College of Cornell University, New York, NY 11237, USA.

PMID: 22552728
DOI: 10.3892/mmr.2012.889

Abstract

Understanding of molecular regulatory pathways presents a novel therapeutic approach for the treatment of head and neck cancer. These specific check points are becoming the targeted therapeutic approach. In this review, we highlight certain major signaling mechanisms, which are involved in the pathophysiology of head and neck cancer. Also, we discuss the current ongoing trials based on the in vitro success of targeted therapies.

Keywords: regulatory pathways; head and neck cancer.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / metabolism
Cyclin-Dependent Kinase Inhibitor p16 / genetics
Cyclin-Dependent Kinase Inhibitor p16 / metabolism
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / metabolism
Humans
Research / trends
Signal Transduction
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism

Substances

Cyclin-Dependent Kinase Inhibitor p16
Tumor Suppressor Protein p53