Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.

Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.

Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.

Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.

Abstract: Systems and methods for providing improved detectors for use in SPECT cameras. The improved detectors use pinhole apertures and surfaces calculated to provide improved sensitivity and resolution. In some embodiments, the detectors have non-planar surfaces. In some embodiments, the surfaces are spherical, conical, parabolic, or other non-planar forms.

Abstract: The invention relates to methods and systems for compensating for respiratory motion of individuals during nuclear imaging. In some embodiments, the methods include obtaining data representing a reference respiratory state for the individual and obtaining data that represents a plurality of respiratory states that correspond to at least a portion of a cycle of respiration of the individual; comparing each of the plurality of respiratory states to a subset of the reference state data to obtain a motion estimate of each of the plurality of respiratory states; compensating for respiratory motion in each of the plurality of respiratory states based on the motion estimates to obtain motion-compensated respiratory state data; and constructing an image using the motion-compensated respiratory state data.

Abstract: Systems and methods for providing improved detectors for use in SPECT cameras. The improved detectors use pinhole apertures and surfaces calculated to provide improved sensitivity and resolution. In some embodiments, the detectors have non-planar surfaces. In some embodiments, the surfaces are spherical, conical, parabolic, or other non-planar forms.