The Younger Laboratory
Engineering molecular tools and cellular systems to model rare genetic variants
Genomic Medicine Center
Children's Mercy Research Institute
At Children's Mercy Kansas City

Rare Genetic Variants: From Discovery To Function

The vast majority of rare diseases in children are thought to result from underlying variations in the sequence of their DNA. However, distinguishing the specific genetic variants that cause disease and deciphering their functional consequences remains a major challenge. The Younger Lab integrates a series of research programs (highlighted below) to accelerate the process of translating the clinical detection of genetic variants into meaningful and actionable biological discoveries.

Variant Identification

Whole Genome
Sequencing

Variant Prioritization

Massively Parallel
Genomic Assays

Genetic
Modeling

Genome Engineering
With CRISPR

Functional
Profiling

Patient Derived
iPSC Systems



Sponsors of our Research Programs:

Dr. Scott Younger, PhD

Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy Kansas City. He has extensive experience working with high-throughput sequencing-based screening technologies and is leading efforts to dissect the molecular mechanisms through which rare genetic variants identified in patients at Children's Mercy lead to disease.

Dr. Younger came to Children's Mercy from the Broad Institute of MIT and Harvard where his group worked on the development of new methodologies to expand the utility of CRISPR-based genetic screens. Prior to working at the Broad Institute he completed his postdoctoral studies at Harvard University as an American Cancer Society Fellow. He holds a Ph.D. in cell and molecular biology from UT Southwestern Medical Center. He also received an M.S. in biotechnology from the University of Texas at San Antonio and a B.S.I. in bioinformatics from Baylor University.

Meet The Team

Scott Younger, PhDPrincipal Investigator

John Means, PhDResearch Scientist

Jasmine McQuerry, PhDPostdoctoral Researcher

Anabel Martinez-Bengochea, PhDPostdoctoral Researcher

Contact Information

Scott Younger, PhD

2401 Gillham Rd / Rm 3902.12
Kansas City, MO 64108
styounger@cmh.edu
(816) 731-7221

Younger Laboratory

Children's Mercy Research Institute
Children's Mercy Kansas City
2401 Gillham Rd / Rm 3902.30
Kansas City, MO 64108