OHSU Faculty Excellence and Innovation Awards

The OHSU Faculty Excellence and Innovation Awards recognize exceptionally creative early- and middle-stage investigators. OHSU deans, directors and chairs nominate a single candidate from their respective schools, programs and departments, and applications are reviewed by prominent scientists from institutions around the country. Finalists and nominees represent the next generation of faculty leaders at OHSU.

The awards are made possible by the Silver Family Innovation Fund. These investments not only catalyze innovation in finalists’ labs but also spark new collaborations that benefit other scientists at OHSU.

Award Winners 2024

Angelica Morales, Ph.D.

Dr. Angelica Morales is an assistant professor of psychiatry. She received a B.A. in Human Biology from Stanford University and a Ph.D. in Neuroscience from the University of California, Los Angeles. She is also an Associate Editor at the journal Drug and Alcohol Dependence. Throughout her career she has been passionate about understanding the mechanisms that underlie substance use disorders to inform the development of evidence-based interventions for prevention and treatment. She uses multimodal neuroimaging to assess brain structure, function, and chemistry, with the goal of understanding the role individual differences in neurobiology play in the initiation, escalation, and maintenance of substance use disorders. Her research also focuses on identifying neurobiological factors the predict treatment outcomes. She has obtained funding from the Oregon Medical Research Foundation, the OHSU Neuroscience Campaign Fund, and the National Institute on Drug Abuse to support her research.

Arpiar “Arpy” Saunders, Ph.D.

Dr. Arpiar “Arpy” Saunders, Ph.D., is currently an assistant professor at the Vollum Institute. Dr. Saunders earned his BA in Biology and Linguistics from Swarthmore College with High Honors. Beginning at the Vollum 2021, the Saunders Lab has focused on developing innovative viral genomic technologies to understand how genetic variation shapes the cellular and synaptic organization of neural circuits. By inventing high-throughput and molecularly-focused strategies to describe the brain’s cellular organization, Arpy aims 1) to understand how precise synaptic networks are formed from diverse brain cell types during development; 2) to integrate insights from human genetics into functional analyses of neural circuits to understand the cellular etiology of neurodevelopmental disorders; and 3) to define the cellular features that specialize the primate brain. In parallel, the Saunders Lab studies the cellular properties of viral infection in the brain, using novel genomic technologies to discover molecules that shape viral interactions across diverse brain cell types. These virology-focused insights simultaneously impact human brain health while also improving viral tools for mapping and manipulating neural circuits. Dr. Saunders has published 21 peer reviewed journal articles across linguistics, genomics, neuroscience and virology, including work in Science, Nature and Cell. He also received the Alfred P. Sloan Foundation Fellowship in Neuroscience, a Rising Star Award from the One Mind Foundation and was a finalist for the McKnight Foundation Scholar Award.

Zheng Xia, Ph.D.

Dr. Zheng Xia is an associate professor in the Department of Biomedical Engineering, as well as a member of the Computational Biology program and Knight Cancer Institute. His lab develops bioinformatics tools for next-generation sequencing data analysis and machine learning algorithms for large-scale biomedical data interpretation. In collaboration with biologists and clinicians, he has used big data bioinformatics analysis to gain novel biological and clinical insights into aging, stem cells, neurological disorders, and cancers. More than 70 peer-reviewed papers have been published through his methodology development and extensive collaborations, including in Nature, Cell, and Science. His current research interests include developing single-cell data analysis algorithms, investigating cancer metastasis and treatment resistance, and advancing cancer immunotherapy.

Award Winners 2023

Miguel Marino, Ph.D.
Associate professor of family medicine, OHSU School of Medicine; and, associate professor, OHSU-Portland State University School of Public Health

Marino was elected to the National Academy of Medicine in 2022. A first-generation Mexican American scientist and associate professor of biostatistics, he chose to apply his expertise in biostatistics in family medicine rather than a traditional faculty pathway, developing a career working alongside community-based clinicians.

Marino will use the award in collaboration with John Heintzman, M.D., M.P.H., to establish a new Latino health research center that will incorporate information about Latino populations in the study of health inequities; build capacity in this area of research by developing an ethnically diverse workforce; and, work to ensure the center’s approach aligns with community needs.

Carmem Pfeifer, D.D.S., Ph.D.
Professor of restorative dentistry (biomaterials and biomechanics), OHSU School of Dentistry

Pfeifer’s research has focused on developing durable, tough polymers combined with antimicrobial additives in dental filling material that’s stronger and lasts twice as long as standard materials used in the field now, and she has demonstrated some success in extending the lifespan of restorations.

Biomedical devices, from dental fillings to artificial hips to shunts in the brain, are all at risk for complications over time. Infections and gradual degradation may lead to potentially life-threatening conditions.

Pfeifer envisions using her award to extend her research in dental materials to other biomedical devices.

Aaron Grossberg, M.D., Ph.D.
Assistant professor of radiation medicine, OHSU School of Medicine; member of the Cancer Early Detection Advanced Research Center, OHSU Knight Cancer Institute, and the Brenden-Colson Center for Pancreatic Care; and, M.D./Ph.D. Program Committee, School of Medicine

Grossberg, who treats patients with pancreatic cancer, has studied early forms of cachexia in mice and plans to apply lessons learned in the lab to identify patients in the earliest stages of cancer-related weight loss — when treatments are most likely to improve their condition.

Grossberg will use his Faculty Excellence and Innovation Award to expand his laboratory’s ability to study how cancer affects the metabolism of fat and muscle, and identify new drug targets to prevent or reverse this process.

Award Winners 2022

Andrew C. Adey, Ph.D.
Associate professor
Department of Molecular Microbiology and Immunology, OHSU School of Medicine
Member of Cancer Early Detection Advanced Research Center, OHSU Knight Cancer Institute

The Adey Lab has pioneered a number of technologies that have made it possible to map changes in cells in response to stimulus or cell exposure.

Adey’s project will take novel approaches to directly address the challenge of providing a complete picture of gene functions in specific cell contexts. The new approaches aim to provide the versatility and power that is needed to interrogate the orchestration of the complex of components. New understandings of these biological systems will be useful to the broad life sciences community and to Adey’s research program, which seeks to learn the fundamental molecular components and interactions that bring functional capabilities to a cell.

Kathleen Carlson, Ph.D.
Associate professor
OHSU-PSU School of Public Health
Core investigator, Health Services Research Center of Excellence, VA Portland Health Care System

Carslon’s project is to coordinate and cultivate efforts to build an OHSU Gun Violence Prevention Research Center that could have both a state and national impact. She will bring together her training and experience in injury and violence epidemiology with her gun violence prevention research to work with an existing network of experts, applied public health practitioners, and students and other trainees

The existing OHSU-PSU Gun Violence as a Public Health Issue Initiative, of which Carlson serves as chair, will be a foundational component of an OHSU center on gun violence prevention research. This initiative, as well as Carlson’s gun violence prevention research, considers how interventions in the health care setting can reduce risk, while also acknowledging and examining the broader socioeconomic factors that contribute to the inequitable burden of this public health issue across the U.S.

Fikadu Tafesse, Ph.D.
Assistant professor
Department of Molecular Microbiology and Immunology, OHSU School of Medicine

The Tafesse Lab is devising a strategy that will make it possible to develop therapeutics and diagnostics that can be readily tailored to treat emerging diseases. They envision a nanobody discovery technology platform that would allow the researchers to generate effective nanobodies against emerging viral pathogens within weeks, instead of months or years.

Using this nanobody discovery approach, they plan to generate nanobodies against prototype viruses from each emerging viral family — coronaviruses, henipaviruses, flaviviruses and bunyaviruses — with the aim of harnessing those nanobodies as therapeutics to combat these deadly diseases.

Brandon Wilder, Ph.D.
Assistant professor
Vaccine and Gene Therapy Institute and Division of Pathobiology and Immunology
Oregon National Primate Research Center

Each year there are 220 million cases of malaria and 400,000 malaria-related deaths. The Wilder lab has built an insectary to grow and maintain malaria-infected mosquitos. They have used this to establish nonhuman primate models of malaria and show that they closely mirror human malaria infection and immunology. These dogma-breaking studies open entirely new avenues of malaria vaccine research, but they are infrastructure-intense, costly and require highly trained and dedicated personnel working over long timelines.

Wilder will use the award to undertake a range of activities, from infrastructure to personnel and travel. The lab will renovate and expand their insectary and hire a full-time insectary technician to rear mosquito species that can also support research on dengue, Zika and other emerging vector-borne pathogens.

Award Winners 2021

Luiz Eduardo Bertassoni, D.D.S., Ph.D.
Associate Professor of Restorative Dentistry, School of Dentistry
CEDAR Member, OHSU Knight Cancer Institute, School of Medicine

Luiz Bertassoni is a clinician-scientist, biomedical engineer and international pioneer in bioprinting. His research led to the development of the first method to 3D bioprint fully vascularized tissue constructs. He has followed that with the development of the method to mimic the 3D cell-laden calcified bone microenvironment with nanoscale precision.

Bertassoni’s project is to develop an innovative technology that will bioprint human tissues with single-cell resolution. This opens the possibility of being able to print replacement organs for patients who would otherwise be waiting on a list. Additionally, these controllable and reproducible automated processes will be used to develop reproducible models of heterogeneous cancers and the tumor microenvironment. With such precise organ systems, experimental drugs could be accurately tested in a lab, rather than a person.

Swetha Murthy, Ph.D.
Assistant Professor, Vollum Institute
Neuroscience Graduate Program, School of Medicine

Molecular neuroscientist Swetha Murthy is uncovering the physiology of mechanotransduction – or the conversion of mechanical force into biological signals. Murthy is specifically focused on mechanically activated ion channels, which are crucial components of the sense of touch, hearing and blood pressure.

Understanding how these ion channels function may unlock answers – and potential treatments – for a wide range of maladies including chronic pain, atherosclerosis, as well as sensitized pain caused by chemotherapy drugs.

The 2021 Faculty Excellence and Innovation Award will support Dr. Murthy’s project, “How do cells sense force and why is it important?”

Award Winners 2020

Jamie Lo, M.D., MCR
Assistant professor of obstetrics and gynecology, OHSU School of Medicine
Division of Reproductive & Developmental Sciences, OHSU Oregon National Primate Research Center

Jamie Lo’s research vision is to understand the effects of marijuana exposure during pregnancy — a topic with significant research gaps. Marijuana is commonly used to help with morning sickness during the first trimester, the period that is most critical for the developing fetus.

Lo is developing an innovative nonhuman primate model that overcomes barriers in human research and facilitates understanding of the prenatal and postnatal effects of chronic maternal marijuana use during pregnancy. Lo’s long-term goal is to establish evidence-driven recommendations and frame policy guidelines for marijuana use in pregnant and lactating women.

Steven Mansoor, M.D., Ph.D.
Assistant professor, OHSU Knight Cardiovascular Institute, OHSU School of Medicine

Cardiologist Steven Mansoor is leading a research effort using cryo-EM to view the structure of receptors whose activation can trigger blood vessel inflammation and platelet aggregation, leading to coronary artery disease.

Mansoor is investigating purinergic receptors, which play important roles in cardiovascular, neuronal and immune systems. The award will allow him to use single particle cryo-electron microscopy, X-ray crystallography and techniques in electrophysiology to study the structure, function and signaling of these receptors. Understanding the function of these receptors may allow researchers to design treatments that can prevent over-activation of these receptors, decreasing heart attacks and plaque burden.

Jeffrey Tyner, Ph.D.
Professor of medicine (cell, developmental, and cancer biology), OHSU School of Medicine, OHSU Knight Cancer Institute

The goal of Jeffrey Tyner’s research program is to improve therapies for patients with leukemia and other blood cancers through a discovery-based platform of functional genomics. Several of his findings have been, and are being, tested in clinical trials, the earliest of which are now complete and likely to lead to regulatory approvals.

The basic premise of this functional genomics platform is to collect as much information as possible from samples of patient cancers — information such as analyses of tumor cell drug sensitivity, signaling, genetics and other cellular processes, as well as data regarding the state of the tumor microenvironment — to mine these expansive patient sample data sets and perform complementary experiments using laboratory models.

Nominees

“These scientists and physician-scientists are nominated for these awards because of their great creativity and promise. They represent some of the most accomplished early- and middle-stage investigators at OHSU and demonstrate the broad base of talent here.” — Peter G. Barr-Gillespie, Ph.D., OHSU executive vice president and chief research officer.

2024

2023

Sandy Christiansen, M.D.
Quin Denfeld, Ph.D., R.N.
Aaron Grossberg, M.D., Ph.D.
Peter Jacobs, Ph.D.
Todd Korthius, M.P.H.
Miguel Marino, Ph.D.
Brian O'Roak, Ph.D.
Alex Ortega Loayza, M.D.
Angela Ozburn, Ph.D.
Ana Paula Piovezan Fugolin, D.D.S., M.S., Ph.D.
Carmen Pfeifer, D.D.S., Ph.D.
Robert Eil, M.D.
Elinor Sullivan, Ph.D.
Cydni Williams, M.D.

2022

2021

2020

Research and Innovation